The Stabilizer Influence on Morphological Characteristics of Poly-(DL-Lactide-Co-Glycolide) Nanospheres

Magdalena Stevanović; Branka Jordović; Zoran Nedić; Dejan Miličević

doi:10.4028/www.scientific.net/MSF.555.447

Paper Titles

Synthesis, Characterization and Biological Activity Evaluation of Novel Pd(II) and Pt(II) Complexes with Heterocyclic Hydrazone Ligands
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Investigation of Antimicrobial Activity of Encapsulated Essential Oils
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A Cu²⁺ Probe over Nizatidine and Ranitidine, or In Silico Vs. Experimentally Obtained Complexation of Drugs
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Release and Diffusion Studies of Hydrogels Based on Itaconic Acid
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The Stabilizer Influence on Morphological Characteristics of Poly-(DL-Lactide-Co-Glycolide) Nanospheres
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The Effect of Processing Parameters on Characteristics of Poly-L-Lactide Microspheres
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Effect of Hyperbranched Vegetable Oil Polyols on Properties of Flexible Polyurethane Foams
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Fraction Scaling and Dynamical Properties of Elastomer Materials
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Effects of Nano-Structure of Silica on Dynamic Properties of Styrene-Butadiene Rubber
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HomeMaterials Science ForumMaterials Science Forum Vol. 555The Stabilizer Influence on Morphological...

The Stabilizer Influence on Morphological Characteristics of Poly-(DL-Lactide-Co-Glycolide) Nanospheres

Abstract:

Copolymer poly(D,L-lactide-co-glycolide) is used for obtaining the systems for controlled delivery of medicaments. Its specific characteristics make it suitable for various researches where its synthesis is performed in different ways. Using the system for controlled delivery of medicaments, an equal concentration of the medicament is achieved in the body throughout an extended period of time and it has advantages over the conventional methods. In this paper we present a new solvent/non-solvent chemical method for obtaining DLPLG nanospheres. In the experiment various stabilizers were used in order to examine their influence on morphological characteristics of DLPLG particles. The samples were characterized by Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) and Stereological analysis.

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Periodical:

Materials Science Forum (Volume 555)

Pages:

447-452

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.555.447

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Online since:

September 2007

Authors:

Magdalena Stevanović, Branka Jordović, Zoran Nedić, Dejan Miličević

Keywords:

Drug Delivery, Nanospheres, Poly(vinyl alcohol), Poly-DL-Lactide-co-Glycolide), Polyvinyl Pyrrolidone (PVP), Stabilizer, Stereological Analysis

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