Ferulic Acid-Loaded Shellac Microparticles Prepared Using Electrohydrodynamic Atomization

Abstract:

An Electrohydrodynamic atomization (EHDA) process was exploited to prepare ferulic acid (FA)-loaded shellac microparticles. SEM observations showed that all the particles were round and solid with their sizes gradually increased from 0.68 ± 0.21 to 2.75 ± 0.64 μm as the concentrations of shellac and FA in ethanol raised from 20% to 50% (w/v). Wide-angle X-ray diffraction analyses demonstrated that FA had been totally converted into an amorphous state in the shellac matrix microparticles. Attenuated total reflectance Fourier transform infrared analysis disclosed that the hydrogen bonding presented between FA and shellac molecules. In vitro dissolution tests verified that all the microparticles were able to provide a fine sustained drug release profile. The release time periods had a close relationship with the diameters of microparticles. All the microparticles released the loaded FA via a typical Fickian diffusion mechanism. The present study provides an easy way to develop novel drug delivery microparticles for providing sustained drug release profiles.

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