Numerical Method on Drug Release from Nanoparticles Using CFD

Abstract:

Nowadays, there are many ways to administer the huge variety of drugs that are on the market. A drug is a chemical substance, that when applied to a living creature, alters its body function. Many drugs are used daily, such as caffeine in coffee and aspirin for pain. A route of drug administration in pharmacology and toxicology is the path by which a drug is brought into contact with the body. The most critical issue is some drugs are not significantly absorbed into the bloodstream. There are thousands of questions on the drug diffusion in the bloodstream and the most common issue is how long will these micro particles drug be released from the tablet Thus, to identify the rate of the drug release and to control the drug release in our body is important, where to meet the target and not to become a waste. The Computational Fluid Dynamics method was used to investigate the drug design and diffusion profiles with time during the process of degradation and diffusion in water.

• Periodical: Journal of Nano Research (Volume 13)
• Pages: 61-68
• DOI: https://doi.org/10.4028/www.scientific.net/JNanoR.13.61
• Online since: February 2011
• Authors: Siti Aslina Hussain, Mohd Imran Rosly, Norhafizah Abdullah
• Keywords: Computational Fluid Dynamics (CFD), Diffusion, Drug, Nanoparticle, Profile, Release

References

[1] M. Grassi, G. Grassi: Mathematical Modeling and Controlled Drug Delivery, Matrix Systems Current Drug Delivery Vol. 2 No. 1 (2005) pp.97-116.

DOI: 10.2174/1567201052772906

[2] R. S. Langer and D. L . Wise in: Medical Applications of Controlled Release, Applications and Evaluation I and II, CRC Press, Florida (1984).

[3] I. Bala, S. Hariharan and M. N. Kumar: PLGA Nanoparticles in Drug Delivery, The State of The Art. Crit. Rev. Ther. Drug Carr. System Vol. 21 (2004) pp.387-482.

DOI: 10.1615/critrevtherdrugcarriersyst.v21.i5.20

[4] B. H. Woo, G. Jiang, W. Yeong and P. P. DeLuca: Preparation and Characterization of a Composite PLGA and Poly(acryloyl hydroxyethyl starch) Microsphere System for Protein Delivery, Pharm. Res. Vol. 18 (2001) pp.1600-1606.

[5] G. Barratt: Colloidal Drug Carriers: Achievements and Perspectives, Cell. Mol. Life Science, Vol. 60 (2003) pp.21-37.

[6] K. Avgoustakis: Pegylated poly(lactide) and Poly(lactide-co-lycolide) Nanoparticles: Preparation, Properties and Possible Applications in Drug Delivery, Curr. Drug Delivery, Vol. 1 (2004) pp.321-333.

DOI: 10.2174/1567201043334605

[7] H. B. Ravivarapu, K. Burton and P. P. DeLuca: Polymer and Icrosphere Blending to Alter the Release of a Peptide from PLGA Microspheres, European Journal Pharm. Biopharm. Vol. 50 (2000) pp.263-270.

DOI: 10.1016/s0939-6411(00)00099-0

[8] S. Ahmed, in: Control Release of Coated Nanoparticles Drug, PhD Thesis, Department of Chemical and Environment, Faculty of Engineering, Universiti Putra Malaysia (2010).

[9] B. Paolo, A. Schoubben, S. Giovagnoli, L. Perioli, M. Ricci and C. Rossi in: Ketoprofen Poly (lactide-co-glycolide) Physical Interaction, Department of Chemistry and Technology of Drugs, University of Perugia, Italy (2007).

DOI: 10.1208/pt0802037

[10] B. Avinash, J. S. Steven and I. W. Karen: Production of Haloperidol-loaded PLGA Nanoparticles for Extended Controlled Drug Release of Haloperidol, Journal of Microencapsulation, Vol. 22 No. 7 (2005) pp.773-785.

DOI: 10.1080/02652040500273753

[11] Information on www. pharmainfo. net/reviews/controlled-released-system-review.