Biocompatibility Study of Mn0.5Zn0.5Fe2O4 Magnetic Nanoparticles

Jing Liu; Jia Zhang; Li Wang; Yun Tao Li; Dong Sheng Zhang

doi:10.4028/www.scientific.net/KEM.483.552

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 483Biocompatibility Study of Mn0.5Zn0.5Fe2O4 Magnetic...

Biocompatibility Study of Mn_0.5Zn_0.5Fe₂O₄ Magnetic Nanoparticles

Abstract:

To explore the preparation method of self-prepared Mn_0.5Zn_0.5Fe₂O₄ magneticnanoparticles and were prepared employing a reduction co-precipitation method, transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (SEM-EDS)were used to characterize the product; The results indicated that the Mn_0.5Zn_0.5Fe₂O₄ magneticnanoparticles were prepared successfully. EDS showed each Mn_0.5Zn_0.5Fe₂O₄magneticnanoparticles contained O, Mn, Zn and Fe elements. The result of heating test showed that Mn_0.5Zn_0.5Fe₂O₄ can serve as a heating source upon AMF exposure leading the magneticnanoparticles to reach its phase transition temperature (41-47.5°C).To evaluate the biocompatibility of Mn_0.5Zn_0.5Fe₂O₄ magnetic nanoparticles, which has the potential application in tumor hyperthermia.In the following study it will be used as drug and gene vector, so the compatibility of it should be examined. Then the use acute toxicity (by the mouse of LD50 test), micronucleus (MN) test and hemolysis test were presented to evaluate the toxicity of it in vivo . Its LD50 arrived at 7.1862 g/kg;Micronucleus test showed micronucleus rate of experiment groups had no significant difference compared with negative group. It has no hemolytic .

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Key Engineering Materials (Volume 483)

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552-558

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.483.552

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Online since:

June 2011

Authors:

Jing Liu, Jia Zhang, Li Wang, Yun Tao Li, Dong Sheng Zhang

Keywords:

Biocompatibility, Mn_0.5Zn_0.5Fe₂O₄, Toxicity

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